C-Ski/V-Ski (AA 551-650) anticorps (HRP)

N° du produit ABIN732947

L’anticorps Lapin Polyclonal anti- a été validé pour WB, ELISA, IHC (fro) et IHC (p). Il convient pour détecter dans des échantillons de Humain.

Aperçu rapide pour C-Ski/V-Ski (AA 551-650) anticorps (HRP) (ABIN732947)

Antigène: C-Ski/V-Ski

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit

Épitope: AA 551-650

Homologie: Human,Mouse,Rat,Dog,Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human C-SKI

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: C-Ski/V-Ski

Sujet:

Synonyms: Sloan-kettering viral oncogene homolog, Avian sarcoma viral v ski oncogene homolog, C oncogene, C ski, Ski oncogene, Ski oncoprotein, SKV, v ski avian sarcoma viral oncogene homolog, v ski sarcoma viral oncogene homolog, v-ski sarcoma viral oncogene homolog, SKI_HUMAN.

Background: SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc.

ID gène: 6497